Palbociclib and letrozole in advanced breast cancer
Letrozole belongs to an aromatase inhibitor class drug used in the treatment of postmenopausal breast cancer. Letrozole is a hormonal therapy combined with Pablociclib for the treatment of HER2-negative, advanced-stage or metastatic, hormone-receptor-positive breast cancer.
Palbociclib and Letrozole use:
Letrozole belongs to hormonal therapy in an aromatase inhibitor class drug used for the treatment of advanced breast cancer. It is Highly Effective when combined with Palbociclib 125 mg.
What causes breast cancer?
The uncontrollable growth of cells in the breast is known as breast cancer. These abnormal cells further invade other parts of the body causing metastatic breast cancer.
The main cause of breast cancer is unknown however it is caused due to DNA mutation in the healthy cell that leads to its continuous division and multiplication. There is some risk factor that increases the chances of breast cancer, these are discussed below:
● Age: The chance of breast cancer rises with increasing age.
● Heredity: It is believed that women are highly prone to risk if their mother or sister is having breast cancer.
What are the initial symptoms of breast cancer?
At the initial stage, there are generally no signs and symptoms of breast cancer however a lump can be felt in some cases. Some of the common symptoms of breast cancer which is developed later are:
● Lump in breast
● Breast pain
● Thickening of surrounding tissues
● Swelling in breast
● Change in size of nipple.
What is stage 4 breast cancer?
At the 4’Th stage of breast cancer the tumor increases its size and metastasis at distant places as well as distant and nearby lymph nodes.
How long does it take breast cancer to develop?
Breast cancer cell needs at least 30 time-divisions before it can be diagnosed by a doctor or by the patient itself. Up to 28 cell divisions can't be detected. Each division takes at least one to two months so if you feel a cancerous lump it has started from two to five years ago.
What are the 5 warning signs of breast cancer?
5 warning signs of breast cancer are:
● Solidifying or lump of part of the breast
● New lump formation in the breast or underarm (armpit)
● Irritation or dimpling of breast skin.
● Pain in the nipple area.
● Redness in the breast.
What are breast cancer Treatments?
There are several methods for the treatment of breast cancer. Few of these are mentioned below:
● Surgery: Surgery means the removal of cancerous tumor forms the best by removing either one breast or both.
● Radiation therapy: This uses a high energy x-ray to kill the cancerous cells.
● Chemotherapy: Chemo drugs directly kill the fast-growing cancer cell. It is given before surgery to shrink the size of the tumor and after surgery to wipe out any remaining cancerous tissue.
● Hormone therapy: These hormone-blocking therapies inhibit the hormones to reach the cancerous cell. These hormones are required by the cancerous cells for cell growth and division.
How many cycles of letrozole to get pregnant?
Almost 22% of the total patient 6 cycles of letrozole was sufficient for a successful pregnancy. For each cycle, letrozole 2.5 mg is combined with 125mg palbociclib for better results. This combined drug is available for worldwide shipment.
