Sirolimus for liver Transplant
What are sirolimus indications for use?
Sirolimus (Trade name Rapamune) is a prescription medication prescribed for preventing the rejection in people aged 13 years and older, have received a kidney transplant.
Sirolimus is prescribed together with other medicines named cyclosporine, and corticosteroids.
It is also prescribed in order to treat lymphangioleiomyomatosis (LAM), which is mainly a rare progressive lung disease that specifically affects predominantly women of the childbearing age.
When was sirolimus approved?
This drug was approved in September 1999 by US FDA and is marketed under the brand name Rapamune by Pfizer.
Who should not consume Sirolimus?
Avoid taking Sirolimus in case you are allergic to it or any of its ingredients.
What should I tell my doctor prior to starting treatment with Sirolimus?
Prior to starting treatment with Sirolimus, inform your healthcare provider if you:
- have liver problems
- complication of skin cancer or have a family history.
- have high cholesterol or triglycerides.
- are pregnant or plan to become pregnant.
- In case you're breastfeeding.
How should I take Sirolimus?
Sirolimus is consumed by mouth 1 time each day. Do not crush, chew, or split the sirolimus tablets. Inform your healthcare provider if you cannot swallow the tablets. Your healthcare provider may prescribe sirolimus as a solution.
Each sirolimus dosage should be taken in the same way, with or without food. Food may affect the amount of medication that gets into the bloodstream. Consuming every dose in the same way helps keep your blood levels of sirolimus more stable.
What should I avoid while taking Sirolimus?
- Do not take live vaccines while during treatment with sirolimus.
- You need to limit your time in sunlight as well as UV light.
Side Effects: The most commonly reported rapamune side effects in people with the renal transplant may include:
high blood pressure
- pain (including stomach and joint pain)
- diarrhea
- headache
- fever
- urinary tract infection
- decreased red blood cell count (anemia)
- nausea
- decreased platelet count
- high blood sugar (diabetes)
Inform your healthcare providers if you have any adverse reactions that bothers you or that is persistent.
What are the sirolimus warnings?
- The rapamune 1mg is contraindicated in patients with known hypersensitivity to this drug.
- Events of bronchial anastomotic dehiscence may occur when this medication is used as an immunosuppressive regimen.
- Those patients who are on immunosuppressive therapy are at higher risk for skin cancer.
- Concomitant use of Rapamune with strong inhibitors of CYP3A4 and/or P-gp should be avoided.
How should I store Sirolimus tablets?
Tablets should be stored at room temperature between 68°F to 77°F (20°C to 25°C).
Sirolimus tablets should be kept in the original blister container and use the outer carton in order to protect blister cards and strips from light. Bottle of sirolimus tablets should be kept tightly closed.
What does rapamune cost?
The sirolimus 1 mg tablet price in india is quite reasonable. The sirolimus 1mg price for a strip of 6 tablets is around 1040 INR.
Note: Before starting treatment with sirolimus, consult a physician. In order to know more about this medication, read full prescribing information.
